منابع مشابه
miR-25, integrin and cancer invasiveness
Prostate cancer is the most common cancer amongst men worldwide and major cause of cancer death. Current treatments of primary prostate tumors are initially effective, however, 25% of the patients develop metastatic disease. Once the cancer has acquired resistance to Androgen Deprivation Therapy, Castration Resistant Prostate Cancer (CRPC) occurs. At this stage, highly aggressive prostate cance...
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Ionizing radiation (IR)-enhanced tumor invasiveness is emerging as a contributor to the limited benefit of radiotherapy; however, its mechanism is still unclear. We previously showed that subcloned lung adenocarcinoma A549 cells (P cells), which survived 10 Gy IR (IR cells), acquired high invasiveness in vitro. Here, we tried to identify the mechanism by which IR cells increase their invasivene...
متن کاملEvaluation of miR-141, miR-200c, miR-30b Expression and Clinicopathological Features of Bladder Cancer
Bladder cancer (BC) ranks the second most common genitourinary tract malignant tumor with high mortality and 70% recurrence rate worldwide. MiRNAs expression has noticeable role in bladder tumorigenesis. The purpose of this study was to assess miR-200c, miR-30b and miR-141 in tissue samples of patients with BC and healthy adjacent tissue samples and their association with muscle invasion, grade...
متن کاملmiR-25 in heart failure.
1 showed miR-25 to reduce levels of rco/endoplasmic reticulum calcium-ATPase (SERCA) 2a during heart failure, whereas therapeutic inhibition of this microRNA (miRNA) was able to reverse pre-established heart failure in a mouse model of pressure overload. Although these data suggest that miR-25 might be a drug target for the treatment of heart failure, further in vivo analysis is required before...
متن کاملmicroRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements
MicroRNAs (miRNAs, micro ribonucleic acids) are pivotal post-transcriptional regulators of gene expression. These endogenous small non-coding RNAs play significant roles in tumorigenesis and tumor progression. miR-142-3p expression is dysregulated in several breast cancer subtypes. We aimed at investigating the role of miR-142-3p in breast cancer cell invasiveness. Supported by transcriptomic A...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.214